NUCB2

Across TCGA patient cohorts, NUCB2 protein abundance is significantly associated with the RNA expression of many other genes, with 16,962 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NUCB2-associated genes across cancer lineages are XBP1, TXNDC11, and SEC11C. Each is linked with NUCB2 in more than 7 cancer types. Because this analysis shows association rather than direction, both NUCB2-to-partner and partner-to-NUCB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NUCB2 versus XBP1 in BRCA, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUCB2→partner) and Y-score (partner→NUCB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	XBP1 →	+1.673	+0.498	<.001	<.001	3	8
OV	TXNDC11 →	+0.457	+0.373	<.001	.001	3	6
COAD	SEC11C →	+0.914	+0.631	<.001	<.001	3	6
UCEC	FICD →	+0.741	+0.686	<.001	<.001	3	6
UCEC	YPEL4 →	-0.904	-0.573	<.001	<.001	3	6
BRCA	AGR2 →	+2.937	+0.452	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,962 associations by consensus.

NUCB2 vs XBP1 — BRCA

Explore this scatter interactively →