NUCB2

Across TCGA patient cohorts, NUCB2 mutation is significantly associated with the RNA expression of many other genes, with 1,595 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUCB2-associated genes across cancer lineages are ATP6V1E1P2, LINC01363, and RNA5SP393. Each is linked with NUCB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUCB2-to-partner and partner-to-NUCB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP6V1E1P2 grouped by NUCB2-low versus NUCB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUCB2→partner) and Y-score (partner→NUCB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP6V1E1P2 →	+0.164	+2.077	<.001	.007	3	2
UCEC	LINC01363 →	+0.079	+1.918	.007	.004	3	2
SKCM	RNA5SP393 →	+0.302	+3.490	<.001	.008	3	2
SKCM	IL9 →	+0.298	+4.037	<.001	.003	3	1
BLCA	OR5T1 →	+0.034	+7.640	<.001	.009	3	1
BLCA	RNA5SP514 →	+0.278	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,595 associations by consensus.

ATP6V1E1P2 by NUCB2 expression — UCEC

Explore this box plot interactively →