NUCB1

Across TCGA pan-cancer cohorts, NUCB1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NUCB1 data layer compared with 18 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher NUCB1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NUCB1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

STAD, SKCM, and UCEC are the cancer types where NUCB1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	II,III,IV	0.001	0.677	<.001	42	view →
SKCM	OS	Median	II,III,IV	0.240	0.844	<.001	30	view →
UCEC	DFS	Median	II,III,IV	1.000	0.438	.016	24	view →
HNSC	DFS	Median	All	0.098	0.710	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUSC	DFS	Median	All	0.132	0.797	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NUCB1–STAD (OS)

Open the STAD breakdown →