NUCB1

Across TCGA pan-cancer cohorts, NUCB1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NUCB1 data layer compared with 18 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUCB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUCB1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where NUCB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.212	0.695	<.001	27	view →
LSCC	OS	Tertile	II,III,IV	0.660	0.927	.004	22	view →
LUAD	DFS	Quartile	II,III,IV	0.661	0.961	.003	13	view →
UCEC	DFS	Median	All	0.932	0.779	.019	10	view →
GBM	DFS	Median	All	0.278	0.460	.006	7	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	6	view →
HNSC	OS	Quartile	III,IV	0.758	0.963	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NUCB1–CCRCC (DFS)

Open the CCRCC breakdown →