NUCB1

Across TCGA patient cohorts, NUCB1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUCB1-associated genes across cancer lineages are ATM, Cyclin-B1, and GATA6. Each is linked with NUCB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NUCB1-to-partner and partner-to-NUCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NUCB1-low versus NUCB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUCB1→partner) and Y-score (partner→NUCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.460	-1.415	.006	.046	3	3
UCEC	Cyclin-B1 →	+0.431	+2.000	.041	.030	3	2
UCEC	GATA6 →	-0.120	-2.307	.039	.033	3	1
UCEC	IGFBP2 →	-0.633	-2.662	.009	<.001	3	1
UCEC	mTOR_pS2448 →	-0.183	-2.169	.001	.003	3	1
UCEC	NF-kB-p65_pS536 →	-0.386	-3.575	.023	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ATM by NUCB1 expression — UCEC

Explore this box plot interactively →