NUCB1

Across TCGA cell cohorts, NUCB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,522 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NUCB1-associated GO terms across cancer lineages are Membrane protein proteolysis, Glycoprotein catabolic process, and Cytosolic transport. Each is linked with NUCB1 in more than 15 cancer types. Because this analysis shows association rather than direction, both NUCB1-to-partner and partner-to-NUCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane protein proteolysis grouped by NUCB1-low versus NUCB1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUCB1→partner) and Y-score (partner→NUCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Membrane protein proteolysis →	+0.153	+1.274	<.001	<.001	3	16
BONE	Glycoprotein catabolic process →	+0.135	+0.872	.001	<.001	3	16
KIDNEY	Cytosolic transport →	+0.069	+1.080	.001	.001	3	15
BREAST	Negative regulation of respiratory burst involved in inflammatory response →	+0.115	+0.737	<.001	.001	3	14
BREAST	Negative regulation of respiratory burst →	+0.115	+0.737	<.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Membrane protein ectodomain proteolysis →	+0.181	+0.980	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,522 associations by consensus.

Membrane protein proteolysis by NUCB1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →