NUCB1

Across TCGA cell cohorts, NUCB1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible NUCB1-associated genes across cancer lineages are EXOSC5, OR10K2, and PABPC1L2B. Each is linked with NUCB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUCB1-to-partner and partner-to-NUCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXOSC5 grouped by NUCB1-low versus NUCB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUCB1→partner) and Y-score (partner→NUCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EXOSC5 →	+0.649	+3.064	<.001	.009	3	1
BREAST	OR10K2 →	+0.047	+4.781	<.001	.003	3	1
BREAST	PABPC1L2B →	+0.309	+4.963	<.001	.001	3	1
BREAST	OR10T2 →	+0.137	+4.781	<.001	.003	3	1
BREAST	METTL11B →	+0.163	+4.421	<.001	.004	3	1
BLOOD_Leukemia	PIP →	+0.082	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EXOSC5 by NUCB1 expression — LARGE_INTESTINE

Explore this box plot interactively →