NUB1

Across TCGA patient cohorts, NUB1 mutation is significantly associated with the RNA expression of many other genes, with 3,934 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUB1-associated genes across cancer lineages are RNU6-986P, TRAJ21, and RNU6-893P. Each is linked with NUB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUB1-to-partner and partner-to-NUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-986P grouped by NUB1-low versus NUB1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUB1→partner) and Y-score (partner→NUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-986P →	+0.547	+3.101	<.001	.003	3	2
COAD	TRAJ21 →	+0.900	+2.823	<.001	.006	3	2
COAD	RNU6-893P →	+0.619	+2.714	<.001	.003	3	2
UCEC	DPEP1 →	-1.074	-2.321	.005	.001	3	2
UCEC	BAG4 →	+0.644	+3.480	<.001	<.001	3	2
UCEC	NDUFV3 →	+0.250	+2.831	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,934 associations by consensus.

RNU6-986P by NUB1 expression — COAD

Explore this box plot interactively →