NUB1

Across TCGA patient cohorts, NUB1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUB1-associated genes across cancer lineages are MSH2, S6_pS240_S244, and ATM. Each is linked with NUB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUB1-to-partner and partner-to-NUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by NUB1-low versus NUB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUB1→partner) and Y-score (partner→NUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.188	-2.973	.042	.035	3	2
UCEC	S6_pS240_S244 →	+0.406	+2.820	.012	.035	3	2
UCEC	ATM →	-0.721	-3.087	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.718	+2.415	.001	.003	3	2
UCEC	eEF2 →	+0.339	+1.906	.018	.016	2	2
UCEC	EGFR_pY1068 →	-0.239	-2.415	.017	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MSH2 by NUB1 expression — UCEC

Explore this box plot interactively →