NUB1

Across TCGA cell cohorts, NUB1 mutation is significantly associated with the RNA expression of many other genes, with 486 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUB1-associated genes across cancer lineages are GCAT, ANKRD54, and DEPDC5. Each is linked with NUB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUB1-to-partner and partner-to-NUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by NUB1-low versus NUB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUB1→partner) and Y-score (partner→NUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.330	+3.169	<.001	.009	3	1
LARGE_INTESTINE	ANKRD54 →	+0.528	+3.067	.001	.009	3	1
LARGE_INTESTINE	DEPDC5 →	+0.690	+3.169	<.001	.009	3	1
LARGE_INTESTINE	PICK1 →	+0.703	+3.364	.002	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.750	+3.451	<.001	.002	3	1
LARGE_INTESTINE	JOSD1 →	+0.587	+3.364	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 486 associations by consensus.

GCAT by NUB1 expression — LARGE_INTESTINE

Explore this box plot interactively →