NUAK1

Across TCGA patient cohorts, NUAK1 mutation is significantly associated with the RNA expression of many other genes, with 2,846 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUAK1-associated genes across cancer lineages are IFI27L1, CDCA5, and MTA2. Each is linked with NUAK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NUAK1-to-partner and partner-to-NUAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFI27L1 grouped by NUAK1-low versus NUAK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUAK1→partner) and Y-score (partner→NUAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IFI27L1 →	+0.524	+1.857	<.001	<.001	3	4
UCEC	CDCA5 →	+0.510	+1.648	.009	.001	3	4
COAD	MTA2 →	+0.354	+2.807	.001	.003	3	3
UCEC	CHEK1 →	+0.478	+2.269	.002	<.001	3	3
COAD	DPEP1 →	-2.459	-2.793	<.001	.003	3	3
UCEC	BUB3 →	+0.394	+2.467	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,846 associations by consensus.

IFI27L1 by NUAK1 expression — UCEC

Explore this box plot interactively →