NUAK1

Across TCGA patient cohorts, NUAK1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUAK1-associated genes across cancer lineages are Caspase-7-cleavedD198, TAZ, and p27_pT157. Each is linked with NUAK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NUAK1-to-partner and partner-to-NUAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NUAK1-low versus NUAK1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUAK1→partner) and Y-score (partner→NUAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.205	+3.186	<.001	.009	3	3
COAD	TAZ →	+0.163	+2.195	.034	.032	3	3
SKCM	p27_pT157 →	+0.125	+3.017	.019	.017	3	3
STAD	c-Kit →	-0.329	-2.321	.021	.034	3	2
UCEC	eIF4E →	+0.239	+2.321	<.001	<.001	3	2
UCEC	ERK2 →	+0.156	+1.459	.012	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by NUAK1 expression — COAD

Explore this box plot interactively →