NUAK1

Across TCGA cell cohorts, NUAK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,544 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NUAK1-associated GO terms across cancer lineages are Positive regulation of cell growth, Negative regulation of protein modification process, and Endodermal cell differentiation. Each is linked with NUAK1 in more than 13 cancer types. Because this analysis shows association rather than direction, both NUAK1-to-partner and partner-to-NUAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell growth grouped by NUAK1-low versus NUAK1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUAK1→partner) and Y-score (partner→NUAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of cell growth →	+0.071	+1.893	.001	<.001	3	14
KIDNEY	Negative regulation of protein modification process →	+0.049	+1.387	<.001	.001	3	14
STOMACH	Endodermal cell differentiation →	+0.212	+2.452	<.001	<.001	3	14
BONE	Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.106	+2.282	<.001	<.001	3	13
STOMACH	Vesicle cargo loading →	+0.135	+2.412	<.001	<.001	3	13
OESOPHAGUS	Protein stabilization →	+0.074	+1.597	.004	.005	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,544 associations by consensus.

Positive regulation of cell growth by NUAK1 expression — OESOPHAGUS

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