NTS

Across TCGA patient cohorts, NTS mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NTS-associated genes across cancer lineages are MAPK_pT202_Y204, Notch1, and GSK-3_pS9. Each is linked with NTS in more than 1 cancer types. Because this analysis shows association rather than direction, both NTS-to-partner and partner-to-NTS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by NTS-low versus NTS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTS→partner) and Y-score (partner→NTS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.600	-3.156	.004	.018	3	2
UCEC	Notch1 →	+0.262	+3.183	<.001	.009	3	2
UCEC	GSK-3_pS9 →	-0.531	-3.321	.003	.010	3	1
UCEC	IRS1 →	+0.234	+2.000	.012	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.203	-3.321	.007	.010	3	1
UCEC	Ku80 →	+0.217	+2.013	.041	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MAPK_pT202_Y204 by NTS expression — UCEC

Explore this box plot interactively →