NTRK2

Across TCGA cell cohorts, NTRK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,850 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NTRK2-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Regulation of myoblast fusion, and ATP synthesis coupled electron transport. Each is linked with NTRK2 in more than 7 cancer types. Because this analysis shows association rather than direction, both NTRK2-to-partner and partner-to-NTRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by NTRK2-low versus NTRK2-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NTRK2→partner) and Y-score (partner→NTRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of syncytium formation by plasma membrane fusion →	+0.052	+1.067	<.001	.001	3	8
LUNG_SCLC	Regulation of myoblast fusion →	+0.071	+1.021	.003	.002	3	8
CNS	ATP synthesis coupled electron transport →	+0.063	+1.089	<.001	.003	3	7
CNS	Mitochondrial ATP synthesis coupled electron transport →	+0.063	+1.089	<.001	.003	3	7
LUNG_SCLC	Mitochondrial electron transport, cytochrome c to oxygen →	+0.071	+0.876	.001	.008	3	6
CNS	Aerobic respiration →	+0.065	+1.103	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,850 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by NTRK2 expression — CNS

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