NTRK2

Across TCGA cell cohorts, NTRK2 mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NTRK2-associated genes across cancer lineages are MAGEB3, SLC32A1, and DAAM2. Each is linked with NTRK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NTRK2-to-partner and partner-to-NTRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB3 grouped by NTRK2-low versus NTRK2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTRK2→partner) and Y-score (partner→NTRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MAGEB3 →	+0.221	+4.044	<.001	.009	3	2
BLOOD_Leukemia	SLC32A1 →	+0.655	+3.034	<.001	.004	3	2
BLOOD_Leukemia	DAAM2 →	+0.852	+3.733	<.001	.002	3	2
BLOOD_Leukemia	DEFB108B →	+0.088	+3.684	<.001	<.001	3	2
BLOOD_Lymphoma	OR2C3 →	+0.014	+3.925	<.001	.006	3	2
LUNG_SCLC	OR4F4 →	+0.012	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

MAGEB3 by NTRK2 expression — LUNG_SCLC

Explore this box plot interactively →