Across TCGA patient cohorts, NTRK1 mutation is significantly associated with the RNA expression of many other genes, with 2,257 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NTRK1-associated genes across cancer lineages are RNA5SP299, CCNB2, and DIS3L. Each is linked with NTRK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NTRK1-to-partner and partner-to-NTRK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTRK1→partner) and Y-score (partner→NTRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	RNA5SP299 →	+0.431	+4.477	<.001	.009	3	4
UCEC	CCNB2 →	+0.764	+2.321	<.001	<.001	3	3
UCEC	DIS3L →	+0.429	+2.272	<.001	.001	3	3
UCEC	RAD51 →	+0.736	+2.332	<.001	<.001	3	3
UCEC	ITGAE →	+0.492	+2.321	<.001	<.001	3	3
UCEC	NUP188 →	+0.558	+1.966	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,257 associations by consensus.

Exploration

NTRK1 survival (RNA) · tumor vs normal (RNA) · all NTRK1 data types