Across TCGA patient cohorts, NTRK1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NTRK1-associated genes across cancer lineages are MEK1, PDCD4, and Caspase-7-cleavedD198. Each is linked with NTRK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NTRK1-to-partner and partner-to-NTRK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTRK1→partner) and Y-score (partner→NTRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.416	+2.000	.001	.003	3	3
UCEC	PDCD4 →	-0.569	-1.896	<.001	.015	3	3
UCEC	Caspase-7-cleavedD198 →	+0.642	+2.000	.002	.029	3	3
SKCM	CDK1 →	+0.130	+1.415	.027	.041	3	3
UCEC	PKC-delta_pS664 →	-0.092	-1.662	.030	.011	3	2
UCEC	TFRC →	+0.503	+2.584	.007	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Exploration

NTRK1 survival (RNA) · tumor vs normal (RNA) · all NTRK1 data types