NTNG1

Across TCGA pan-cancer cohorts, NTNG1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated NTNG1 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher NTNG1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NTNG1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

ESCA, ACC, and LUSC are the cancer types where NTNG1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	III,IV	0.074	0.574	<.001	24	view →
ACC	OS	Median	All	0.273	0.802	.017	15	view →
LUSC	OS	Median	II,III,IV	0.337	0.622	.006	10	view →
UCEC	DFS	Median	II,III,IV	0.890	0.429	.017	8	view →
SKCM	OS	Median	All	0.923	0.772	.014	7	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →
COAD	OS	Median	II,III,IV	0.561	0.861	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

NTNG1–ESCA (OS)

Open the ESCA breakdown →