NTN4

Across TCGA pan-cancer cohorts, NTN4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NTN4 data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NTN4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NTN4 expression acts as an unfavorable survival marker.

UCEC, GBM, and LSCC are the cancer types where NTN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.356	1.000	.040	8	view →
GBM	DFS	Median	All	0.270	0.543	.025	2	view →
LSCC	DFS	Quartile	II,III,IV	0.862	1.000	.045	2	view →
HNSC	OS	Tertile	II,III,IV	0.947	1.000	.039	1	view →
LUAD	OS	Tertile	II,III,IV	0.857	1.000	.035	1	view →
PDAC	OS	Median	II,III,IV	0.830	0.862	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NTN4–UCEC (DFS)

Open the UCEC breakdown →