NTN4

Across TCGA patient cohorts, NTN4 mutation is significantly associated with the RNA expression of many other genes, with 2,180 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NTN4-associated genes across cancer lineages are PPP2R2D, PSMC3IP, and TXNL4A. Each is linked with NTN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both NTN4-to-partner and partner-to-NTN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R2D grouped by NTN4-low versus NTN4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTN4→partner) and Y-score (partner→NTN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PPP2R2D →	+0.332	+1.957	.001	.002	3	3
UCEC	PSMC3IP →	+0.571	+2.137	<.001	.009	3	3
UCEC	TXNL4A →	+0.343	+2.627	.005	.005	3	3
SKCM	HAUS8 →	+0.292	+1.970	.009	.002	3	3
UCEC	COX15 →	+0.357	+3.592	.005	.001	3	2
UCEC	TBRG1 →	+0.373	+2.445	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,180 associations by consensus.

PPP2R2D by NTN4 expression — SKCM

Explore this box plot interactively →