NTN4

Across TCGA patient cohorts, NTN4 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NTN4-associated genes across cancer lineages are ATM, Caspase-8, and C-Raf. Each is linked with NTN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NTN4-to-partner and partner-to-NTN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NTN4-low versus NTN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTN4→partner) and Y-score (partner→NTN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.379	-1.678	.029	.023	3	2
UCEC	Caspase-8 →	-0.258	-2.880	.007	.001	3	2
UCEC	C-Raf →	+0.200	+2.584	<.001	.010	3	2
UCEC	Di-Ras3 →	-0.151	-3.308	.007	.009	3	2
SKCM	EGFR_pY1173 →	-0.076	-3.000	.045	.034	3	1
SKCM	Snail →	-0.157	-2.446	.026	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by NTN4 expression — UCEC

Explore this box plot interactively →