NTM

Across TCGA cell cohorts, NTM mutation is significantly associated with the RNA expression of many other genes, with 214 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NTM-associated genes across cancer lineages are CCDC63, KRT72, and IQCF1. Each is linked with NTM in more than 1 cancer types. Because this analysis shows association rather than direction, both NTM-to-partner and partner-to-NTM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC63 grouped by NTM-low versus NTM-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTM→partner) and Y-score (partner→NTM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCDC63 →	+0.032	+4.584	.002	.001	3	1
LUNG_NSCLC_LUAD	KRT72 →	+0.024	+3.605	.003	.007	3	1
LUNG_NSCLC_LUAD	IQCF1 →	+0.163	+3.628	<.001	.006	3	1
LUNG_NSCLC_LUAD	PLET1 →	+0.053	+3.584	<.001	.007	3	1
LUNG_NSCLC_LUAD	POM121L12 →	+0.015	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR6J1 →	+0.028	+4.285	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 214 associations by consensus.

CCDC63 by NTM expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →