NTHL1

Across TCGA pan-cancer cohorts, NTHL1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NTHL1 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NTHL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NTHL1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where NTHL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.919	0.617	.005	13	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	9	view →
LUAD	OS	Tertile	All	0.959	0.655	.004	8	view →
CCRCC	OS	Tertile	All	1.000	0.711	.031	6	view →
GBM	DFS	Tertile	All	0.515	0.315	.020	6	view →
HNSC	DFS	Quartile	All	0.525	0.757	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NTHL1–LSCC (DFS)

Open the LSCC breakdown →