NTHL1

Across TCGA cell cohorts, NTHL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,602 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NTHL1-associated GO terms across cancer lineages are Pyrimidine deoxyribonucleoside triphosphate metabolic process, Enzyme-directed rRNA pseudouridine synthesis, and Negative regulation of cell activation. Each is linked with NTHL1 in more than 13 cancer types. Because this analysis shows association rather than direction, both NTHL1-to-partner and partner-to-NTHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pyrimidine deoxyribonucleoside triphosphate metabolic process grouped by NTHL1-low versus NTHL1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NTHL1→partner) and Y-score (partner→NTHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Pyrimidine deoxyribonucleoside triphosphate metabolic process →	+0.156	+0.699	<.001	.001	3	14
BONE	Enzyme-directed rRNA pseudouridine synthesis →	+0.111	+0.836	<.001	<.001	3	12
BREAST	Negative regulation of cell activation →	-0.075	-0.609	<.001	<.001	3	11
BONE	Wound healing →	-0.125	-0.946	<.001	<.001	3	11
BLOOD_Lymphoma	T cell lineage commitment →	-0.157	-0.784	<.001	<.001	3	11
OVARY	Defense response to bacterium →	-0.085	-0.706	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,602 associations by consensus.

Pyrimidine deoxyribonucleoside triphosphate metabolic process by NTHL1 expression — BREAST

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