NT5DC3

Across TCGA patient cohorts, NT5DC3 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NT5DC3-associated genes across cancer lineages are ATM, EGFR_pY1068, and EGFR. Each is linked with NT5DC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NT5DC3-to-partner and partner-to-NT5DC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NT5DC3-low versus NT5DC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NT5DC3→partner) and Y-score (partner→NT5DC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.358	-2.571	.025	.010	3	2
UCEC	EGFR_pY1068 →	-0.283	-2.392	.001	<.001	3	1
UCEC	EGFR →	-0.142	-2.000	.012	.030	3	1
UCEC	eIF4E →	+0.172	+2.335	.021	.018	3	1
UCEC	A-Raf_pS299 →	-0.123	-2.321	.003	.005	3	1
UCEC	JNK2 →	+0.246	+2.594	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ATM by NT5DC3 expression — UCEC

Explore this box plot interactively →