NT5DC3

Across TCGA cell cohorts, NT5DC3 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NT5DC3-associated genes across cancer lineages are OTOR, OPRPN, and MYH6. Each is linked with NT5DC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NT5DC3-to-partner and partner-to-NT5DC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOR grouped by NT5DC3-low versus NT5DC3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NT5DC3→partner) and Y-score (partner→NT5DC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OTOR →	+0.022	+4.087	<.001	.009	3	1
URINARY_TRACT	OPRPN →	+0.045	+4.087	<.001	.009	3	1
URINARY_TRACT	MYH6 →	+0.029	+4.217	<.001	.005	3	1
URINARY_TRACT	PRAMEF9 →	+0.010	+4.087	<.001	.009	3	1
BLOOD_Leukemia	PRAMEF1 →	+0.012	+5.569	<.001	.001	3	1
BLOOD_Leukemia	GPR42 →	+0.031	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

OTOR by NT5DC3 expression — URINARY_TRACT

Explore this box plot interactively →