NT5C3AP2

Across TCGA pan-cancer cohorts, NT5C3AP2 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated NT5C3AP2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NT5C3AP2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated NT5C3AP2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and KICH are the cancer types where NT5C3AP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.440	0.287	<.001	115	view →
SKCM	OS	Median	All	0.419	0.254	<.001	92	view →
KICH	DFS	Tertile	II,III,IV	0.338	1.000	<.001	79	view →
LUAD	OS	Median	III,IV	0.823	0.480	<.001	69	view →
BLCA	DFS	Quartile	II,III,IV	0.522	0.258	<.001	67	view →
OV	OS	Tertile	All	0.442	0.276	.001	60	view →
BRCA	DFS	Median	III,IV	0.631	0.355	.003	52	view →
LGG	DFS	Tertile	All	0.236	0.431	<.001	42	view →
CHOL	DFS	Tertile	All	0.769	0.238	.004	21	view →
DLBC	DFS	Quartile	All	0.532	0.896	.010	21	view →
LAML	DFS	Tertile	All	0.534	0.310	.015	20	view →
ESCA	DFS	Quartile	III,IV	0.593	0.238	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

NT5C3AP2–HNSC (OS)

Open the HNSC breakdown →