NT5C1A

Across TCGA patient cohorts, NT5C1A mutation is significantly associated with the RNA expression of many other genes, with 2,202 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NT5C1A-associated genes across cancer lineages are TOMM22, TXN2, and MED31. Each is linked with NT5C1A in more than 2 cancer types. Because this analysis shows association rather than direction, both NT5C1A-to-partner and partner-to-NT5C1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOMM22 grouped by NT5C1A-low versus NT5C1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NT5C1A→partner) and Y-score (partner→NT5C1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TOMM22 →	+0.427	+2.758	.001	<.001	3	3
UCEC	TXN2 →	+0.297	+2.609	.007	.006	3	3
UCEC	MED31 →	+0.516	+3.424	<.001	<.001	3	3
UCEC	MRPL37 →	+0.464	+2.550	.001	<.001	3	3
UCEC	ERP27 →	-1.193	-2.896	<.001	.001	3	3
UCEC	LONP1 →	+0.616	+2.747	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,202 associations by consensus.

TOMM22 by NT5C1A expression — UCEC

Explore this box plot interactively →