NT5C1A

Across TCGA patient cohorts, NT5C1A mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NT5C1A-associated genes across cancer lineages are PCNA, TFRC, and 4E-BP1. Each is linked with NT5C1A in more than 1 cancer types. Because this analysis shows association rather than direction, both NT5C1A-to-partner and partner-to-NT5C1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by NT5C1A-low versus NT5C1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NT5C1A→partner) and Y-score (partner→NT5C1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.213	+3.584	.017	.002	3	2
UCEC	TFRC →	+0.582	+2.459	.007	.019	3	2
UCEC	4E-BP1 →	+0.281	+3.199	.012	.009	3	2
UCEC	Cyclin-B1 →	+0.731	+3.321	.001	.009	3	2
SKCM	Rictor_pT1135 →	-0.183	-3.144	.029	.018	2	2
UCEC	A-Raf_pS299 →	-0.171	-3.000	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PCNA by NT5C1A expression — UCEC

Explore this box plot interactively →