NT5C

Across TCGA pan-cancer cohorts, NT5C mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NT5C data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NT5C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NT5C expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where NT5C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.638	0.442	.005	24	view →
CCRCC	DFS	Tertile	III,IV	0.742	0.340	.002	15	view →
HNSC	OS	Median	II,III,IV	0.950	1.000	.014	6	view →
GBM	DFS	Tertile	All	0.455	0.769	.015	4	view →
LUAD	OS	Median	III,IV	0.265	0.837	.023	4	view →
LSCC	OS	Median	All	1.000	0.813	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NT5C–PDAC (OS)

Open the PDAC breakdown →