NSUN4

Across TCGA pan-cancer cohorts, NSUN4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NSUN4 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NSUN4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NSUN4 expression acts as an unfavorable survival marker.

CCRCC, LSCC, and GBM are the cancer types where NSUN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.264	0.757	.003	16	view →
LSCC	DFS	Median	All	0.542	0.917	.002	7	view →
GBM	DFS	Quartile	All	0.228	0.439	.033	2	view →
HNSC	DFS	Tertile	III,IV	0.911	1.000	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NSUN4–CCRCC (DFS)

Open the CCRCC breakdown →