NSUN4

Across TCGA patient cohorts, NSUN4 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSUN4-associated genes across cancer lineages are PRAS40_pT246, eIF4E, and A-Raf_pS299. Each is linked with NSUN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSUN4-to-partner and partner-to-NSUN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by NSUN4-low versus NSUN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSUN4→partner) and Y-score (partner→NSUN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.176	+2.999	.015	.035	3	2
UCEC	eIF4E →	+0.242	+4.000	.006	<.001	3	1
UCEC	A-Raf_pS299 →	-0.144	-2.999	.004	.035	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.375	+1.594	.038	.042	3	1
UCEC	Heregulin →	-0.121	-2.986	.021	.035	3	1
UCEC	INPP4B →	-0.461	-3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PRAS40_pT246 by NSUN4 expression — UCEC

Explore this box plot interactively →