NSUN3

Across TCGA pan-cancer cohorts, NSUN3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NSUN3 data layer compared with 20 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher NSUN3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NSUN3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

STAD, HNSC, and SKCM are the cancer types where NSUN3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.184	0.730	.001	33	view →
HNSC	OS	Median	All	0.139	0.685	.003	24	view →
SKCM	DFS	Median	All	0.088	0.757	<.001	12	view →
UCS	OS	Median	All	0.153	0.687	.019	6	view →
UCEC	DFS	Median	All	1.000	0.632	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NSUN3–STAD (OS)

Open the STAD breakdown →