NSUN3

Across TCGA pan-cancer cohorts, NSUN3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated NSUN3 data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NSUN3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NSUN3 expression acts as an unfavorable survival marker.

HNSC and LSCC are the cancer types where NSUN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.333	0.908	.001	34	view →
LSCC	OS	Tertile	II,III,IV	0.423	0.974	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

NSUN3–HNSC (OS)

Open the HNSC breakdown →