NSUN3

Across TCGA patient cohorts, NSUN3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSUN3-associated genes across cancer lineages are INPP4B, Notch1, and SLC1A5. Each is linked with NSUN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSUN3-to-partner and partner-to-NSUN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by NSUN3-low versus NSUN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSUN3→partner) and Y-score (partner→NSUN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.333	-3.169	.040	.019	3	1
UCEC	Notch1 →	+0.180	+2.820	.011	.035	3	1
UCEC	SLC1A5 →	-0.423	-2.314	.048	.035	3	1
UCEC	VHL →	-1.210	-3.321	<.001	.010	3	1
UCEC	TFRC →	+0.583	+3.000	.028	.036	2	1
UCEC	Caspase-8 →	-0.330	-2.321	.008	.034	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

INPP4B by NSUN3 expression — UCEC

Explore this box plot interactively →