NSUN3

Across TCGA cell cohorts, NSUN3 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NSUN3-associated genes across cancer lineages are OR10A3, OR6P1, and IL5. Each is linked with NSUN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSUN3-to-partner and partner-to-NSUN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A3 grouped by NSUN3-low versus NSUN3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSUN3→partner) and Y-score (partner→NSUN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR10A3 →	+0.062	+5.029	<.001	.006	3	1
BLOOD_Leukemia	OR6P1 →	+0.023	+5.201	<.001	.006	3	1
LARGE_INTESTINE	IL5 →	+0.122	+3.977	<.001	<.001	3	1
LARGE_INTESTINE	TSFM →	+0.581	+3.192	<.001	.007	3	1
LARGE_INTESTINE	C1QL2 →	+0.004	+3.421	.002	<.001	3	1
LARGE_INTESTINE	GPX4 →	+0.603	+3.064	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR10A3 by NSUN3 expression — LUNG_SCLC

Explore this box plot interactively →