NSUN3

Across TCGA cell cohorts, NSUN3 mutation is significantly associated with the mutation status of many other genes, with 3,410 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NSUN3-associated genes across cancer lineages are MARCO, ANK1, and MYOM2. Each is linked with NSUN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSUN3-to-partner and partner-to-NSUN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MARCO grouped by NSUN3-low versus NSUN3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSUN3→partner) and Y-score (partner→NSUN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MARCO →	+2.807	+2.678	.006	.006	1	2
LUNG_SCLC	ANK1 →	+2.843	+4.193	.007	.007	1	2
SOFT_TISSUE	MYOM2 →	+4.502	+5.066	.007	.007	1	2
SOFT_TISSUE	CALCR →	+4.502	+5.066	.007	.007	1	2
LARGE_INTESTINE	SLC6A16 →	+2.129	+2.504	.007	.007	1	2
LARGE_INTESTINE	ATP2C2 →	+2.070	+2.807	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,410 associations by consensus.

MARCO by NSUN3 expression — LARGE_INTESTINE

Explore this box plot interactively →