NSUN2

Across TCGA pan-cancer cohorts, NSUN2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NSUN2 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NSUN2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NSUN2 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where NSUN2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.716	0.895	.011	26	view →
LUAD	OS	Median	All	0.645	1.000	.002	11	view →
PDAC	OS	Quartile	III,IV	0.500	1.000	.022	5	view →
GBM	DFS	Median	All	0.494	0.273	.019	4	view →
HNSC	OS	Quartile	IV	0.600	0.847	.045	2	view →
LSCC	DFS	Quartile	All	0.304	1.000	.017	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NSUN2–CCRCC (DFS)

Open the CCRCC breakdown →