NSUN2

Across TCGA patient cohorts, NSUN2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSUN2-associated genes across cancer lineages are NDRG1_pT346, Src_pY527, and EGFR_pY1068. Each is linked with NSUN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NSUN2-to-partner and partner-to-NSUN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDRG1_pT346 grouped by NSUN2-low versus NSUN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSUN2→partner) and Y-score (partner→NSUN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDRG1_pT346 →	-0.359	-1.440	.024	.022	3	3
UCEC	Src_pY527 →	-0.346	-1.668	.013	.021	3	3
UCEC	EGFR_pY1068 →	-0.213	-1.807	.009	.024	3	2
UCEC	Gab2 →	+0.252	+1.222	.029	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.136	-1.678	.012	.021	3	2
UCEC	Notch1 →	+0.148	+2.009	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

NDRG1_pT346 by NSUN2 expression — UCEC

Explore this box plot interactively →