NSUN2

Across TCGA cell cohorts, NSUN2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NSUN2-associated genes across cancer lineages are MYH1, C3orf85, and NEUROG1. Each is linked with NSUN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSUN2-to-partner and partner-to-NSUN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH1 grouped by NSUN2-low versus NSUN2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSUN2→partner) and Y-score (partner→NSUN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MYH1 →	+0.022	+5.000	<.001	.006	3	1
PANCREAS	C3orf85 →	+0.132	+5.000	<.001	.006	3	1
BLOOD_Lymphoma	NEUROG1 →	+0.006	+5.643	<.001	.002	3	1
OVARY	PPY →	+0.217	+4.029	<.001	.009	3	1
OVARY	KRTAP1-1 →	+0.076	+4.450	.002	.004	3	1
SKIN	GPR119 →	+0.022	+4.196	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MYH1 by NSUN2 expression — PANCREAS

Explore this box plot interactively →