NSMF

Across TCGA patient cohorts, NSMF mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSMF-associated genes across cancer lineages are VHL, 14-3-3_beta, and eIF4E. Each is linked with NSMF in more than 1 cancer types. Because this analysis shows association rather than direction, both NSMF-to-partner and partner-to-NSMF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by NSMF-low versus NSMF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSMF→partner) and Y-score (partner→NSMF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.834	-1.584	.001	.036	3	2
UCEC	14-3-3_beta →	-0.090	-2.295	.022	.033	3	1
UCEC	eIF4E →	+0.169	+2.459	.041	.019	3	1
UCEC	A-Raf_pS299 →	-0.154	-2.807	<.001	.003	3	1
UCEC	FOXO3a_pS318_S321 →	-0.104	-2.115	.033	.016	3	1
UCEC	JNK2 →	+0.261	+2.502	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

VHL by NSMF expression — UCEC

Explore this box plot interactively →