NSMF

Across TCGA cell cohorts, NSMF mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NSMF-associated genes across cancer lineages are SSMEM1, OR1L6, and OR2J2. Each is linked with NSMF in more than 1 cancer types. Because this analysis shows association rather than direction, both NSMF-to-partner and partner-to-NSMF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSMEM1 grouped by NSMF-low versus NSMF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSMF→partner) and Y-score (partner→NSMF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SSMEM1 →	+0.023	+3.707	.008	.009	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR2J2 →	+0.019	+4.217	<.001	.001	3	1
LARGE_INTESTINE	OR5V1 →	+0.008	+4.437	<.001	.004	3	1
LARGE_INTESTINE	MARCOL →	+1.186	+3.920	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SSMEM1 by NSMF expression — LARGE_INTESTINE

Explore this box plot interactively →