NSMCE4A

Across TCGA pan-cancer cohorts, NSMCE4A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NSMCE4A data layer compared with 21 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NSMCE4A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NSMCE4A expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where NSMCE4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.879	0.572	<.001	29	view →
CCRCC	OS	Quartile	All	1.000	0.767	.001	27	view →
HNSC	OS	Tertile	III,IV	1.000	0.226	.013	23	view →
LUAD	DFS	Tertile	All	0.942	0.664	.032	4	view →
PDAC	OS	Median	III,IV	1.000	0.587	.022	3	view →
GBM	OS	Quartile	All	0.681	0.379	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NSMCE4A–LSCC (DFS)

Open the LSCC breakdown →