Across TCGA patient cohorts, NSMCE3 protein abundance is significantly associated with the RNA expression of many other genes, with 13,626 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NSMCE3-associated genes across cancer lineages are SMC6, PARP2, and METTL4. Each is linked with NSMCE3 in more than 6 cancer types. Because this analysis shows association rather than direction, both NSMCE3-to-partner and partner-to-NSMCE3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSMCE3→partner) and Y-score (partner→NSMCE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC6 →	+0.603	+0.239	<.001	<.001	3	7
HNSC	PARP2 →	+0.649	+0.272	.002	<.001	3	6
LSCC	METTL4 →	+0.608	+0.287	<.001	<.001	3	6
HNSC	SMCHD1 →	+0.508	+0.267	<.001	<.001	3	6
GBM	CENPM →	+1.039	+0.319	<.001	<.001	3	5
HNSC	VRK1 →	+1.183	+0.302	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,626 associations by consensus.

Exploration

NSMCE3 survival (RNA) · tumor vs normal (RNA) · all NSMCE3 data types