Across TCGA patient cohorts, NSMCE3 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSMCE3-associated genes across cancer lineages are C-Raf, MSH2, and PEA-15_pS116. Each is linked with NSMCE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSMCE3-to-partner and partner-to-NSMCE3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSMCE3→partner) and Y-score (partner→NSMCE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.192	+3.000	.020	.037	3	1
UCEC	MSH2 →	-0.347	-3.000	.009	.037	1	1
UCEC	PEA-15_pS116 →	+0.446	+3.000	.028	.037	1	1
UCEC	Tuberin →	+0.372	+3.000	.017	.037	1	1
UCEC	YB-1 →	+0.216	+3.026	.018	.019	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

NSMCE3 survival (RNA) · tumor vs normal (RNA) · all NSMCE3 data types