NSMCE2

Across TCGA patient cohorts, NSMCE2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSMCE2-associated genes across cancer lineages are ERK2, STAT3_pY705, and ATM. Each is linked with NSMCE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSMCE2-to-partner and partner-to-NSMCE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by NSMCE2-low versus NSMCE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSMCE2→partner) and Y-score (partner→NSMCE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.299	+3.169	.004	.020	3	1
UCEC	STAT3_pY705 →	-0.376	-3.169	.008	.020	3	1
UCEC	ATM →	-0.630	-3.169	.011	.020	3	1
UCEC	PCNA →	+0.338	+3.169	.004	.020	2	1
UCEC	c-Jun_pS73 →	-0.211	-3.169	.015	.020	2	1
UCEC	EGFR_pY1068 →	-0.326	-3.169	.018	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ERK2 by NSMCE2 expression — UCEC

Explore this box plot interactively →