NSMCE1

Across TCGA pan-cancer cohorts, NSMCE1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NSMCE1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NSMCE1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NSMCE1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where NSMCE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.494	0.801	.005	42	view →
LSCC	DFS	Median	All	0.808	0.618	.013	24	view →
LUAD	DFS	Tertile	All	0.766	0.471	.007	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NSMCE1–HNSC (DFS)

Open the HNSC breakdown →