NSMAF

Across TCGA patient cohorts, NSMAF mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSMAF-associated genes across cancer lineages are PCNA, INPP4B, and Rad50. Each is linked with NSMAF in more than 2 cancer types. Because this analysis shows association rather than direction, both NSMAF-to-partner and partner-to-NSMAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by NSMAF-low versus NSMAF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSMAF→partner) and Y-score (partner→NSMAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.200	+1.807	.006	.004	3	3
UCEC	INPP4B →	-0.302	-2.321	.006	.005	3	2
UCEC	Rad50 →	-0.189	-1.514	.022	.015	3	2
COAD	Annexin-1 →	+0.609	+3.330	<.001	.005	3	2
UCEC	TFRC →	+0.411	+2.321	.023	.033	3	2
UCEC	ATM →	-0.583	-3.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

PCNA by NSMAF expression — UCEC

Explore this box plot interactively →