NSMAF

Across TCGA cell cohorts, NSMAF mutation is significantly associated with the RNA expression of many other genes, with 130 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NSMAF-associated genes across cancer lineages are OR10C1, OR1D4, and NLRP8. Each is linked with NSMAF in more than 1 cancer types. Because this analysis shows association rather than direction, both NSMAF-to-partner and partner-to-NSMAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10C1 grouped by NSMAF-low versus NSMAF-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSMAF→partner) and Y-score (partner→NSMAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR10C1 →	+0.040	+4.681	<.001	.003	3	2
BLOOD_Leukemia	OR1D4 →	+0.046	+4.539	<.001	.007	3	2
OESOPHAGUS	NLRP8 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	KLHL34 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	PPIAL4F →	+0.060	+4.906	<.001	.006	3	1
LUNG_SCLC	IRGC →	+0.028	+3.220	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 130 associations by consensus.

OR10C1 by NSMAF expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →